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Inaugural lecture

June 2018
On June 22, Prof.dr. Michiel van Agtmael held his inaugural lecture on clinical pharmacology and pharmacotherapy education at the VU University in Amsterdam. His main conclusion was that prescribing is a complex process and that undergraduate education in prescribing during should be improved. To this end, he argues that innovative teaching methods should be developed and implemented in the medical curriculum. Watch a part of the lecture here (in Dutch). On the same day, a symposium entitled 'Teaching and learning out of a box' was organised. Teams had to compete with each other to design the most innovative teaching method for learning prescribing. One team won the prize with their idea of a game 'Escape Room for prescribing'.

ZonMW Grant

May 2018
RECIPE has received a ZonMw Grant together the Radboudumc for developing a national medication safety assessment. Students have to pass this assessment at the end of the medical curriculum. It is recognized that certain drug groups cause the majority of preventable serious adverse reactions. The assessment focuses on essential drugs. Medical students are expected to know its mechanism of action, side effects that may cause serious harm, associated risk factors, contributing comedication, and measures to prevent and to treat side effects. More information about this assessment can be found here.

EACPT Focus Meeting on education

April 2018
The University of Birmingham will host a EACPT Focus Meeting on education from Friday 7th to Saturday 8th September 2018. The aim of the meeting will be to present innovations from across Europe as well as have updates on pedagogical theory and research. The conference will aim to be inclusive and of interest to all levels of clinical pharmacologist – whether new to teaching or experienced in the field. Register now.

Thesis Award!

April 2018
On April 13, Jelle Tichelaar has won the Thesis Award of the the Dutch Society of Clinical Pharmacology and Biopharmacy (NVKF&B) for his PhD thesis entitled 'Making better prescribers during a context-based pharmactherapy learning programme'. Congratulations!

PhD thesis completed

March 2018
On March 28, Tim Schutte succesfully defended his PhD dissertation entitled 'Learning in a Student-Run Clinic: A new concept to improve medical education in pharmacotherapy'. His thesis consisted of 8 peer reviewed articles. He found that a Student-Run Clinic is an innovative and effective way of teaching rational prescribing to medical students during the undergraduate medical curriculum. It offers benefits to medical education as well as patient care. His entire thesis can be downloaded here.

PhD thesis completed

March 2018
On March 15, David Brinkman succesfully defended his PhD dissertation entitled 'Rational prescribing in Europe: Are future doctors well prepared? His thesis consisted of 9 peer reviewed articles. He argues that nearly graduated doctors in Europe currently lack essential competencies required for rational prescribing because of shortcomings in undergraduate clinical pharmacology and therapeutics education. Several Dutch news papers published an item about his research (see Paper 1, Paper 2, Paper 3). His entire thesis can be downloaded here.

Innovation Grant

February 2018
The Student-Run Clinic at the VU University Medical Center has recently received a €100.000 VUmc Innovation Grant to start and analyze the benefits of a student-led adverse drug event managing team in VUmc. The junior-adverse drug event managers (J-ADEMs) will coordinate all aspects of adverse drug reactions (ADRs) by screening hospitalized patients, taking in-depth medication history, reporting adverse drug reactions and providing causality assessments and the pharmacological explanations to the ward physician and patients. This ultimate pharmacovigilance educational method will increase students and ward physician competences in adverse drug reaction (reporting) and has the opportunity to increase patient safety.

Happy new year!

January 2018
RECIPE would like to wish you a prosperous and healthy 2018! We are looking forward to collaborate and develop new research projects in order to improve rational prescribing in Europe and elswhere.










What should medical students in Europe know about clinical pharmacology?

December 2017
What should medical students know and be able to do in order to prescribe rationally by the time they graduate? And, how should we teach and assess prescribing during the undergraduate medical education in Europe? These were the two questions in our new study, which has just been published in Clinical Pharmacology & Therapeutics.
Together with 92 teachers from 25 European countries (Network of Teachers in Pharmacotherapy), we have defined 252 learning outcomes that should be included in undergraduate curricula to ensure that European graduates are able to rationally. Furthermore, we have developed a blueprint of a European core curriculum in describing when and how these learning outcomes might be taught and assessed (see figure below). We hope that this collaborative project is another important step towards better prescribing in Europe! The manuscript can be accessed here.

Side visit at RECIPE

December 2017
In December, Lenka Souckova and professor Regina Demlova from Masaryk University in Czech Republic visited RECIPE to share educational experiences.

They had the following comments regarding their visit:
"We found the visit absolutely helpful and fruitful. It was a great occasion to compare syllabus in pharmacology within individual disciplines and semesters to reach final consensus and develop a list of key curricular outcomes for clinical pharmacology and therapeutics education during the undergraduate medical curriculum in Europe. Your innovative approach to students and new methods of teaching, focused on students’ skills to apply their knowledge to clinical practise, was very inspiring for us. We appreciated especially high activity and motivation of your students during workshops and seminars. It is enviable how you manage the interconnection between pharmacotherapy teaching and its application to clinical practise, when students may evaluate and prepare suggestions of pharmacotherapy of real patients during their learning."

New student-run clinic

October 2017
A new interprofessional student-run clinic (initiated by RECIPE) has been introduced in the VU University Medical Center. In this clinic, medical students work in teams together with nursing and pharmacy students. They conduct therapeutics consultations with polypharmacy patient under the supervision of a geriatrist. They learn how to optimise the therapeutic regimen of these patients as a team. Also, they learn how to communicate the therapeutic plans with the patients and their relatives, and are responsible for the follow-up.

New professor

September 2017
Michiel van Agtmael has been appointed professor of Pharmacotherapy Education at the VU University Medical Center on the 1st of September 2017. He has been working at VU University Medical Center since 2001 as an internist-infectiologist. Michiel is the successor to Prof.dr. Theo de Vries who retired in 2013. Michiel is also the new chair of the Education Working Group of the European Association of Clinical Pharmacology and Therapeutics (EACPT).







Oncology nurses receive qualification

July 2017
Seventeen Master Oncology nurses completed the 14-month training programme provided by RECIPE and are now certified to prescribe drugs. Congratulations!






Award nomination

July 2017
The interprofessional student-run clinic 'Learning by doing' initiated by Jelle Tichelaar, Michiel van Agtmael, Michael Reumerman and Erik Donker has been nominated for the VU Innovation Award. Also, Jelle Tichelaar has been nominated for the Teacher Talent Award of the VU University Amsterdam.

EACPT Congress in Prague

June 2017
The RECIPE group has attended the congress of the European Association of Clinical Pharmacology and Therapeutics (EACPT) in Prague. The congress took place from the 24th to the 27th of June. In total, 2 oral presentations and 6 poster presentations were provided by RECIPE members. A new record! All our presentations and posters can be downloaded here.

Training completed

June 2017
RECIPE members Jelle Tichelaar , Tim Schutte and David Brinkman completed their training in clinical pharmacology at the VU University Medical Center in Amsterdam. They are now officically registered as a clinical pharmacologist in The Netherlands. Congratulations!

New publication in the JAMA Internal Medicine!

May 2017
RECIPE has published a new intervention study about improving appropriate antimicrobial prescribing in hospitals. The Dutch Unique Method for Antimicrobial Stewardship (DUMAS) study was a prospective, stepped-wedge, participatory intervention study. The study was performed at 7 clinical departments (2 medical, 3 surgical, and 2 pediatric) in a tertiary care medical center and a general teaching hospital in the Netherlands. We offered prescribers a free choice of how to improve their antimicrobial prescribing. Prescribers were stimulated to choose interventions with higher potential for success based on a root cause analysis of inappropriate prescribing. The mean antimicrobial appropriateness increased from 64% at intervention start to 77% at 12-month follow-up, without a change in slope. This study shows that the use of a behavioral approach preserving prescriber autonomy resulted in an increase in antimicrobial appropriateness sustained for at least 12 months. The manuscript can be accessed here.

Education Award

April 2017
David Brinkman has won the Education Award 2017 of the Dutch Society of Clinical Pharmacology and Biopharmacy (NVKF&B). He has contributed in developing a European network to improve clinical pharmacology and therapeutics education across Europe. This has resulted in two publications in Clinical Pharmacology & Therapeutics. Further studies will be conducted to develop a European core curriculum in clinical pharmacology and therapeutics.

New publication in Clinical Pharmacology & Therapeutics!

March 2017
In collaboration with the EACPT, RECIPE has published a second European study. In this multicenter study, we evaluated the current structure, delivery and assessment of CPT education in the European Union (EU). 185 medical schools (64%) from 27 EU countries responded. Traditional learning methods were mainly used. The majority of respondents did not provide students with the opportunity to practise real-life prescribing and believed that their students were not well prepared for prescribing. There is a marked difference in the quality and quantity of CPT education within and between EU countries, suggesting that there is considerable scope for improvement. A collaborative approach should be adopted to harmonise and modernise the undergraduate CPT education across the EU. The manuscript can be accessed here.

PhD thesis completed

December 2016
On the 9th of December 2016, Jelle Tichelaar successfully defended his PhD thesis about a context-based pharmacotherapy education. His thesis consisted of 10 peer reviewed articles. He argued that medical students should gain experience in prescribing in real clinical practice as early as possible during medical training. Also, teachers should be aware that giving medical students responsibility for real patients during clinical clerkships has a large impact on the development of students' prescribing competencies. His entire PhD thesis can be downloaded here.

Are European medical graduates competent prescribers?

November 2016
In collaboration with the EACPT, RECIPE has published the first study of essential competencies in prescribing among European medical students. In this international multicenter study, the researchers evaluated the essential knowledge, skills, and attitudes in clinical pharmacology and therapeutics (CPT) of 895 final-year medical students across Europe. In a cross-sectional design, 26 medical schools from 17 European countries were asked to administer a standardized assessment and questionnaire to 50 final-year students. Although there were differences between schools, results showed an overall lack of essential prescribing competencies among final-year students in Europe. Students had a poor knowledge of drug interactions and contraindications, and chose inappropriate therapies for common diseases or made prescribing errors. These important findings results suggest that undergraduate teaching in CPT is inadequate in many European schools, leading to incompetent prescribers and potentially unsafe patient care. The manuscript can be accessed here.

Students and doctors are unaware of the cost of drugs they frequently prescribe

November 2016
RECIPE published a new study to gain insight into the attitude and knowledge of medication costs of medical students and doctors in daily practice. This study was a cross-sectional electronic survey among medical students and doctors. Attitude to costs was evaluated using a cost-consciousness scale. In open questions, the participants estimated the cost of commonly prescribed drugs. Overall, a reasonable cost-consciousness was found. Estimated drug costs were often not correct. The price of generic drugs was frequently overestimated and that of proprietary drugs was underestimated. While doctors and students considered it important to be aware of the cost of drugs, this attitude is not reflected in their ability to estimate the cost of frequently prescribed drugs. Cost awareness is important in therapeutic reasoning and cost-effective prescribing. Both should be better addressed in pharmacotherapy education. The manuscript can be freely accessed here.
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